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Home - Products - GPCR/G Protein - Antibacterial - Genz 669178

Genz 669178

CAS No. 1254834-91-7

Genz 669178( Genz669178 )

Catalog No. M11036 CAS No. 1254834-91-7

A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.

A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Genz 669178
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
  • Description
    A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei; demonstrates in vitro potency against the 3D7 and Dd2 strains of P. falciparum, good tolerability and oral exposure in the mouse, and ED(50) values in the 4-day murine P. berghei efficacy model of 13-21 mg/kg/day with oral twice-daily dosing.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Genz669178
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1254834-91-7
  • Formula Weight
    322.386
  • Molecular Formula
    C17H14N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C(N2C3=CC=CC(C#N)=C3N=C2C)S1)NC4CC4
  • Chemical Name
    5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. 2. Booker ML, et al. J Biol Chem. 2010 Oct 22;285(43):33054-64. 3. Skerlj RT, et al. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13.
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