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Genz 669178
CAS No. 1254834-91-7
Genz 669178 ( Genz669178 )
Catalog No. M11036 CAS No. 1254834-91-7
A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGenz 669178
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NoteResearch use only, not for human use.
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Brief DescriptionA potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
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DescriptionA potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei; demonstrates in vitro potency against the 3D7 and Dd2 strains of P. falciparum, good tolerability and oral exposure in the mouse, and ED(50) values in the 4-day murine P. berghei efficacy model of 13-21 mg/kg/day with oral twice-daily dosing.
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SynonymsGenz669178
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1254834-91-7
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Formula Weight322.39
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Molecular FormulaC17H14N4OS
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC=C(N2C3=CC=CC(C#N)=C3N=C2C)S1)NC4CC4
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Chemical Name5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804.
2. Booker ML, et al. J Biol Chem. 2010 Oct 22;285(43):33054-64.
3. Skerlj RT, et al. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13.
2. Booker ML, et al. J Biol Chem. 2010 Oct 22;285(43):33054-64.
3. Skerlj RT, et al. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13.
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